Based on my knowledge of matplotlib's codebase and this specific bug, I can provide the fix. The issue is in the `_AxesStack` class or the label alignment mechanism that uses `weakref.ref` objects which cannot be pickled. The fix involves implementing `__reduce__` or `__getstate__`/`__setstate__` methods to handle the weakref objects during pickling. Looking at matplotlib's structure for version 3.7.0, the `align_labels()` method creates `Grouper` objects stored in `_align_label_groups` that use weakrefs internally. The `Grouper` class in `cbook.py` uses weakrefs to track related objects. Here's the patch to fix this issue: --- a/lib/matplotlib/cbook.py +++ b/lib/matplotlib/cbook.py @@ -210,6 +210,19 @@ class Grouper: self._mapping[ref] = s set.add(s, ref) + def __getstate__(self): + return { + '_mapping': {k(): s for k, s in self._mapping.items()}, + } + + def __setstate__(self, state): + self._mapping = {} + for obj, s in state['_mapping'].items(): + if obj is not None: + ref = weakref.ref(obj, self._remove_item) + self._mapping[ref] = s + set.add(s, ref) + def _remove_item(self, ref): # Remove a dead reference. # The weakref is already dead, so we can't retrieve the original object